Life Sciences

New life sciences research from Zhejiang University described

Published in Cancer Weekly, June 10th, 2008

According to a study from Hangzhou, People's Republic of China, "Claudins are integral membrane proteins essential in tight junction formation and function. Altered expression of claudins has been implicated in epithelial malignant transformation."

"We report here that activation of recepteur d'origine nantais (RON) differentially regulates tight junction function and claudin expression. In Martin-Darby canine kidney (MDCK) cells, macrophage-stimulating protein-induced RON activation or expression of constitutively active variant RON160 significantly disrupted cellular tight junctions and reduced transepithelial electrical resistance. These changes were featured by...

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Source: Cancer Weekly (2008-06-10)

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