Cancer Weekly
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Adenocarcinoma
Scientists at Chiba University, Medical Department target adenocarcinoma
June 10th, 2008
According to recent research published in the journal Histopathology, "Hepatoid adenocarcinomas are clinically chemoresistant; however, data concerning the mechanisms of chemoresistance are lacking. ATP-binding cassette (ABC) transporters play a role in the ATP-dependent outward efflux of drugs, and their function renders tumour cells multidrug resistant." "We assumed that the expression of ABC transporters may be accompanied by hepatic differentiation because most ABC transporters are dominantly expressed in hepatocytes. The aim of this study was to investigate the expression of ABC transporters in hepatoid adenocarcinomas. The expression of P-glycoprotein,...
Source: Cancer Weekly (2008-06-10)
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