Non-Small Cell Lung Cancer
Recent studies by M. Beaufaller and co-authors add new data to non-small cell lung cancer findings
Published in Cancer Weekly, June 10th, 2008
According to recent research from Strasbourg, France, "Recent clinical success of epidermal growth factor (EGFR)-tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) have raised hopes that targeting other deregulated growth factor signaling, such as the hepatocyte growth factor/MET pathway, will lead to new therapeutic options for NSCLC. Furthermore, NSCLC present secondary EGFR-TKIs resistance related to exons 20 and 19 EGFR mutations or more recently to MET amplification."
"The aim of this study was to determine MET copy number related to EGFR copy number and K-Ras mutations in a targeted TKI naive NSCLC cohort. We investigated 106 frozen tumors...
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Source: Cancer Weekly (2008-06-10)
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