Cancer Weekly
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Angiogenesis
Researchers' work from University of Bari, Medical Department focuses on angiogenesis
June 10th, 2008
"The effects of amino-bisphosphonate clodronate on endothelial cell functions involved in angiogenesis, namely proliferation and morphogenesis on matrigel were tested in vitro, whereas its effects on angiogenesis were studied in vivo. This was performed by using the chick embryo chorioallantoic membrane (CAM) assay," researchers in Bari, Italy report. "In vitro, clodronate inhibited the endothelial cell proliferation in a dose-dependent fashion, peaking at 30 mc M. At the same concentration, clodronate inhibited the fibroblast growth factor-2 (FGF-2)-induced capillary-like tube formation in the morphogenesis assay on matrigel. In vivo, when tested with the CAM assay,...
Source: Cancer Weekly (2008-06-10)
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