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Angiogenesis

Reports outline angiogenesis study findings from University of Wisconsin, Department of Biochemistry

Published in Cancer Weekly, June 10th, 2008

Scientists discuss in 'Genetic selection for peptide inhibitors of angiogenin' new findings in angiogenesis. "The improper regulation of angiogenesis is implicit in a variety of diseases, including cancer. Angiogenin is unique among angiogenic factors in having ribonucleolytic activity," researchers in the United States report.

"Inhibitors of this activity could serve as chemotherapeutics. The ribonucleolytic activity of angiogenin is toxic to the Origami strain of Escherichia coli. Herein, this cytotoxicity was used to identify inhibitors from a random nonapeptide library tethered to the C-terminus of human angiogenin. The selected sequences fell into three...

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