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Apoptosis
Researchers at American University of Beirut publish new data on apoptosis
June 10th, 2008
"Previously, we have reported that 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide (DCQ) is a radiosensitizer. Here, we investigate the mechanism of radiosensitization," investigators in Beirut, Lebanon report. "EMT6 cells were treated with DCQ for 4 h prior to ionizing radiation (IR). Flow cytometry, clonogenic assay, TUNEL, and Western blotting were performed to assess the effect of treatment on cells. Propidium iodide staining of EMT6 cells treated with IR DCQ revealed high numbers of cells with decreased DNA, consistent with an apoptotic response. TUNEL assay revealed apoptosis was 4%, 38%, and 49% 24 h after treatment with IR alone, DCQ alone, and DCQ + IR,...
Source: Cancer Weekly (2008-06-10)
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