Barrett Esophagus

Data from K. Evangelou and colleagues advance knowledge in barrett esophagus

Published in Cancer Weekly, June 10th, 2008

According to a study from Athens, Greece, "E2F-1 expression is positively associated with tumour growth in oesophageal squamous-cell carcinomas (OSCC), while it exhibits oncosuppressive features in colonic adenocarcinomas (AC). To date there are no data regarding E2F-1 expression and its relationship with tumour kinetics (proliferation, apoptosis) in adenocarcinomas that develop on Barrett oesophagus."

"As oesophageal adenocarcinomas occur almost exclusively in the metaplastic Barrett epithelium and the opposing E2F-1 behaviour seems to be cell and tissue-type dependent, we examined the manner in which E2F-1 acts in ACs of Barrett oesophagus. We estimated the...

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Source: Cancer Weekly (2008-06-10)

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