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Bladder Cancer
Findings in bladder cancer reported from Medical University of Innsbruck
June 10th, 2008
According to a study from Innsbruck, Austria, "We investigated the value of multiple cell cycle markers for their prognostic impact on overall survival and recurrence-free survival in urothelial carcinoma (UC). A tissue microarray consisting of 99 UCs was evaluated for the expression of p53, p16, p21, p27, cyclin D1, cyclin E, Bcl-2, Ki-67 and PCNA." "Statistical analysis was performed applying Kaplan-Meier and Cox regression models using receiver operator characteristic curves for determination of markers' cutoffs. Expression above the cutoffs of Ki-67, p53 and p27, particularly in high-grade and early-stage UC, was associated with worse overall survival, while...
Source: Cancer Weekly (2008-06-10)
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