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Enzyme Research
Studies from C.L. White and colleagues reveal new findings on enzyme research
June 10th, 2008
According to recent research from London, the United Kingdom, "Escherichia coli nitroreductase (NTR) converts the prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) into a bifunctional alkylating agent that causes DNA crosslinks. In this study, the ability of NTR to enhance the combined effects of CB1954 and radiation has been tested in vitro and in vivo." "Stably transduced ovarian cancer cells (SKOV3-NTR) that are sensitive to CB1954 (IC50=0.35 mc M) demonstrated enhanced cytotoxicity when treated with CB1954 and single-fraction irradiation. The NTR - CB1954 system mediated a bystander effect in combination with radiation on transfer of conditioned medium from...
Source: Cancer Weekly (2008-06-10)
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