Cancer Weekly
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Gene Therapy
New gene therapy study findings reported from Queen's University
June 17th, 2008
According to recent research from North Ireland, "Driving high-level transgene expression in a tumour-specific manner remains a key requirement in the development of cancer gene therapy. We have previously demonstrated the strong anticancer effects of generating abnormally high levels of intracellular NO center dot following the overexpression of the inducible nitric oxide synthase (iNOS) gene." "Much of this work has focused on utilizing exogenously activated promoters, which have been primarily induced using X-ray radiation. Here we further examine the potential of the pE9 promoter, comprising a combination of nine CArG radio-responsive elements, to drive the iNOS...
Source: Cancer Weekly (2008-06-17)
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