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Cancer Weekly

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Cancer Gene Therapy



New cancer gene therapy research from Malmo University described



June 17th, 2008

Researchers detail in 'TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells,' new data in cancer gene therapy. According to recent research from Malmo, Sweden, "Amplification of the TNK2 gene in primary tumours correlates with poor prognosis. In accordance, TNK2 overexpression was shown to promote invasion of cancer cells--but the mechanism by which TNK2 mediates these effects is unresolved."

"TNK2 was suggested to regulate Cdc42-driven migration by activation of breast cancer antioestrogen resistance 1 (BCAR1); however, distinct from this effect is evidence for a role of TNK2 in...


Source: Cancer Weekly (2008-06-17)

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