Tuberous Sclerosis
New tuberous sclerosis study findings have been reported by scientists at Harvard University
Published in Cancer Weekly, June 17th, 2008
According to recent research published in the journal Molecular Cell, "Mammalian target of rapamycin, mTOR, is a major sensor of nutrient and energy availability in the cell and regulates a variety of cellular processes, including growth, proliferation, and metabolism. Loss of the tuberous sclerosis complex genes (TSC1 or TSC2) leads to constitutive activation of mTOR and downstream signaling elements, resulting in the development of tumors, neurological disorders, and at the cellular level, severe insulin/IGF-1 resistance."
"Here, we show that loss of TSC1 or TSC2 in cell lines and mouse or human tumors causes endoplasmic reticulum (ER) stress and activates the...
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Source: Cancer Weekly (2008-06-17)
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