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Antisense Technology
Study results from Y.F. He and colleagues in the area of antisense technology published
June 17th, 2008
According to a study from Guangzhou, People's Republic of China, "5-fluorouracil (5-FU) is still a widely used anticancer drug. More than 85% of the 5-FU administered is catabolized by dihydropyrimidine dehydrogenase (DPD) in the liver." "However, mutations in the DPD gene have been found to be associated with low DPD activity causing severe complications. The purpose of this study was to determine the mutation frequency of four exons in Chinese cancer patients and the relationship between genotype and DPD activity. Samples from 142 cancer patients were investigated in this study. The DPD activity was determined by reversed-phase HPLC. Exons 2, 13, 14 and 18 were...
Source: Cancer Weekly (2008-06-17)
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