Life Sciences

Studies from Nara Medical University, Department of Biology in the area of life sciences described

Published in Cancer Weekly, June 17th, 2008

Scientists discuss in 'Hdm2 and nitric oxide radicals contribute to the p53-dependent radioadaptive response' new findings in life sciences. According to a study from Nara, Japan, "The aim of this work was to characterize the radioadaptive response at the molecular level. We used wild-type (wt) p53 and mutated (m) p53-containing cells derived from the human lung cancer H1299 cell line, which is p53-null."

"Cellular radiation sensitivities were determined with a colony-forming assay. The accumulations of p53, the human homolog of endogenous murine double minute 2 (Hdm2), and inducible nitric oxide synthase were analyzed with Western blotting. Quantification of...

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Source: Cancer Weekly (2008-06-17)

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