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Cancer Gene Therapy
Data from Sichuan University advance knowledge in cancer gene therapy
June 17th, 2008
In this recent study, researchers in People's Republic of China conducted a study "To explore the specific killing effect on prostate cancer cells of a dual cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT) expression plasmid system controlled by the prostate-specific membrane antigen (PSMA) promoter and enhancer. The CD gene was used to construct the recombinant plasmid prostate-specific membrane antigen(promoter/enhancer)-CD (pPSMA(E/P)-CD)." "The specific regulatory function of the pPSMA(E/P) promoter was demonstrated by detection of enhanced green fluorescent protein (EGFP) expression in the LNCaP cell line. Survival of cells transfected with...
Source: Cancer Weekly (2008-06-17)
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