Research

Outing the outliers: Strategy matches oncogene with subtype of prostate cancer

Published in Cancer Weekly, June 24th, 2008

A new study reveals a previously unidentified candidate oncogene that appears to play a significant role in a subset of prostate cancers. The research, published by Cell Press in the June issue of the journal Cancer Cell, describes a new strategy that can be used to find "outlier" genes in cancer subtypes that are not well understood.

"We know that ETS gene fusions occur in 40%-80% of prostate-specific antigen (PSA)-screened prostate cancers, leaving 20%-60% of prostate cancers in which the key genetic aberration is unknown. Further, we have shown that ETS-positive and –negative cancers have distinct transcriptional signatures, suggesting that unique oncogenes and...

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Source: Cancer Weekly (2008-06-24)

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