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Cancer Gene Therapy
Scientists at Netherlands Cancer Institute, Division of Molecular Genetics report research in cancer gene therapy
June 24th, 2008
Research findings, 'Cellular senescence in vivo: a barrier to tumorigenesis,' are discussed in a new report. "Cellular senescence is characterized by a largely irreversible cell cycle arrest that can be triggered by many types of intrinsic and extrinsic stress. These include telomere malfunction, oncogene activation and tumor suppressor gene inactivation," researchers in Netherlands report. "Ultimately, such events culminate in the activation of a tumor suppressor gene network. Since the first description of Oncogene-Induced cellular Senescence (OIS) little over a decade ago, many subsequent studies have confirmed that OIS prevents cells from undergoing oncogenic...
Source: Cancer Weekly (2008-06-24)
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