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Cancer Gene Therapy Cell Biology
Data on cancer gene therapy cell biology reported by researchers at Ohio State University, Comprehensive Cancer Center
June 24th, 2008
Fresh data on cancer gene therapy are presented in the report 'Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.' "Fhit protein is lost in most cancers, its restoration suppresses tumorigenicity, and virus-mediated FHIT gene therapy induces apoptosis and suppresses tumors in preclinical models. We have used protein cross-linking and proteomics methods to characterize a Fhit protein complex involved in triggering Fhit-mediated apoptosis," researchers in the United States report. "The complex includes Hsp60 and Hsp10 that mediate Fhit stability and may affect import into mitochondria, where it...
Source: Cancer Weekly (2008-06-24)
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