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Cancer Gene Therapy
Reports outline cancer gene therapy research from Kaohsiung Medical University
June 24th, 2008
"Increasing the specificity of chemotherapy may improve the efficacy of cancer treatment. Toward this aim, we developed a strain of bacteria to express enzymes for selective prodrug activation and non-invasive imaging in tumors. beta-glucuronidase and the luxCDABE gene cluster were expressed in the DH5 alpha strain of Escherichia coli to generate DH5 alpha-lux/beta G. These bacteria emitted light for imaging and hydrolyzed the glucuronide prodrug 9ACG to the topoisomerase 1 inhibitor 9-aminocamptothecin ( 9AC)," scientists writing in the journal Cancer Gene Therapy report. "By optical imaging, colony-forming units ( CFUs) and staining for beta G activity, we...
Source: Cancer Weekly (2008-06-24)
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