Cancer Weekly
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Acute Myeloid Leukemia
Studies from B. Hackanson et al add new findings in the area of acute myeloid leukemia
June 24th, 2008
According to recent research from Freiburg, Germany, "Functional loss of CCAAT/enhancer binding protein alpha (C/ EBP alpha), a master regulatory transcription factor in the hematopoietic system, can result in a differentiation block in granulopoiesis and thus contribute to leukemic transformation. Here, we show the effect of epigenetic aberrations in regulating C/EBP alpha expression in acute myeloid leukemia (AML)." "Comprehensive DNA methylation analyses of the CpG island of C/EBP alpha identified a densely methylated upstream promoter region in 51% of AML, patients. Aberrant DNA methylation was strongly associated with two generally prognostically favorable...
Source: Cancer Weekly (2008-06-24)
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