Cancer Weekly
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B-Cell Lymphoma
Reports outline B-cell lymphoma research from College of Medicine
June 24th, 2008
According to a study from the United States, "Transcription factors play a central role in malignant transformation by activating or repressing waves of downstream target genes. Therapeutic targeting of transcription factors can reprogram cancer cells to lose their advantages in growth and survival." "The BCL6 transcriptional repressor plays a central role in the pathogenesis of diffuse large B-cell lymphomas (DLBCL) and controls downstream checkpoints, including the p53 tumor suppressor gene. We report that a specific inhibitor of BCL6 called BPI can trigger a p53 response in DLBCL cells. This was partially due to induction of p53 activity and partially due to relief...
Source: Cancer Weekly (2008-06-24)
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