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Cancer Weekly

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B-Cell Lymphoma



Scientists at University of Oxford target B-cell lymphoma



June 24th, 2008

"Circulating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43)," scientists in Oxford, the United Kingdom report.

"Levels were higher in patient than control sera (P = 0.009, 0.02 and 0.04 respectively). Moreover, high MIRN21 expression was associated with relapse-free survival (P = 0.05)," wrote C.H. Lawrie and colleagues, University of Oxford.

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Source: Cancer Weekly (2008-06-24)

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