Cancer Weekly
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Cancer Vaccines
Study data from Washington University, Medical Department update knowledge of cancer vaccines
July 1st, 2008
" Mammaglobin-A (MGB) is a breast cancer-associated antigen that is an attractive target for immune intervention. MGB has been shown to induce a specific CD8 T cell response in breast cancer patients, but little is known about a possible MGB-specific CD4 T cell response," scientists in the United States report. " Peripheral blood-derived CD4(+)CD25-T cells were stimulated in vitro with MGB-pulsed antigen-presenting cells (APC). The MGB and human leukocyte antigen (HLA) class II specificity of the CD4 T cell lines was confirmed by cytokine release following restimulation with autologous and allogenic APC pulsed with MGB from different sources. Candidate HLA class...
Source: Cancer Weekly (2008-07-01)
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