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Cancer Gene Therapy
Research on cancer gene therapy detailed by M. Schiappacassi and co-authors
July 1st, 2008
Researchers detail in 'p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis,' new data in cancer gene therapy. "The tumor suppressor gene CDKN1B encodes for a 27-kDa cyclin-dependent kinase inhibitory protein, p27Kip1, which together with its well-established role in the inhibition of cell proliferation, displays additional activities in the control of gene transcription and cell motility. p27Kip1 thus represents a good candidate for a gene therapy approach, especially in those cancers refractory to the conventional therapies, like human glioblastoma. Here, we show that overexpression of p27Kip1 in glioblastoma cell lines induced cell cycle arrest...
Source: Cancer Weekly (2008-07-01)
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