Cancer Weekly
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Cancer Gene Therapy
Research reports from Y. Gupta and co-authors provide new insights into cancer gene therapy
July 1st, 2008
A new study, 'Vitamin B12-mediated transport: a potential tool for tumor targeting of antineoplastic drugs and imaging agents,' is now available. "The uptake of vitamin B12 (cyanocobalamin, Cbl/VB12) in mammalian cells is mediated by specific, high-affinity receptors for the vitamin B12-binding protein, transcobalamin II, which is expressed on the plasma membrane. The receptor for vitamin B12 is overexpressed on a number of human tumors, including cancers of the ovary, kidney, uterus, testis, brain, colon, lung, and myelocytic blood cells," scientists writing in the journal Critical Reviews™ In Therapeutic Drug Carrier Systems report. "Furthermore, the affinity...
Source: Cancer Weekly (2008-07-01)
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