Cancer Weekly
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Cancer Gene Therapy
Researchers at University College, Conway Institute of Biomolecular and Biomedical Research target cancer gene therapy
July 1st, 2008
Researchers detail in 'Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism,' new data in cancer gene therapy. "Small interfering RNAs (siRNAs) represent a novel tool to induce gene silencing in mammalian cells and clinical trials are currently ongoing to assess the therapeutic efficacy of siRNAs in various human diseases, including age-related macular degeneration and respiratory syncytial virus infection. However, previously reported off-target, nonspecific effects of siRNAs, including activation of type I IFNs and proinflammatory cytokines, remain an...
Source: Cancer Weekly (2008-07-01)
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