Gene Therapy
Osaka University details research in gene therapy
Published in Cancer Weekly, July 1st, 2008
A report, 'Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants,' is newly published data in Virology. "Adenoviral vector (Ad)-mediated gene transfer is an attractive method for manipulating the immunostimulatory properties of dendritic cells (DCs) for cancer immunotherapy. DCs treated with Ad have phenotype alterations (maturation) that facilitate T cell sensitization," researchers in Suita, Japan report.
"We investigated the mechanisms of DC maturation with Ad transduction. Expression levels of a maturation marker (CD40) on DCs treated with conventional Ad, fiber-modified Ads (AdRGD, AdF35, AdF35DeltaRGD), or a...
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Source: Cancer Weekly (2008-07-01)
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