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Hepatomas

New hepatomas study findings recently were published by researchers at Peking University

Published in Cancer Weekly, July 1st, 2008

According to a study from Beijing, People's Republic of China, "Jaspolide B is a novel isomalabaricane-type triterpene isolated from sponge Jaspis sp. We investigated its effects on human hepatoma cells in this study."

"After 48 It of incubation, jaspolide B inhibited the growth of Bel-7402 and HepG2 cells with IC50 values of 29.1 and 29.5 mc M, respectively. Incubation with 0.5 mc M of jaspolide B caused time-dependent induction of apoptosis in up to 66.8% of Bel-7402 cells for 48 h, and the induction of apoptosis was confirmed by the enhancement of mitochondrial masses and cell membrane permeability, and nuclear condensation in Bel-7402 and HepG2 cells. Moreover,...

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