Cancer Weekly
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Acute Myeloid Leukemia
Study results from University of Munich provide new insights into acute myeloid leukemia
July 1st, 2008
" Alkylphosphocholines represent a new class of cytostatic drugs with a novel mode of action. Erufosine (ErPC3), the first compound of this class that can be administered intravenously, has recently been shown to be active against human tumor and leukemic cell lines," researchers in Munich, Germany report. " In order to evaluate the antileukemic potential of ErPC3 in acute myeloid leukemia (AML) the lethal concentration 50% (LC 50) was determined using WST-1 assay. For analysis of cell death, staining for Annexin V and activated caspase 3 was performed. An interaction analysis was performed by calculation of combination index and construction of isobolograms. The LC 50...
Source: Cancer Weekly (2008-07-01)
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