Adverse Drug Reactions

Studies from L.A. Andritsos et al add new findings in the area of adverse drug reactions

Published in Cancer Weekly, July 1st, 2008

According to a study from the United States, " Lenalidomide is a novel therapeutic agent with uncertain mechanism of action that is clinically active in myelodysplastic syndrome (MDS) and multiple myeloma (MM). Application of high (MM) and low (MDS) doses of lenalidomide has been reported to have clinical activity in CLL."

"Herein, we highlight life-threatening tumor flare when higher doses of lenalidomide are administered to patients with CLL and provide a potential mechanism for its occurrence. Patients and Methods Four patients with relapsed CLL were treated with lenalidomide (25 mg/d for 21 days of a 28-day cycle). Serious adverse events including tumor flare and...

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Source: Cancer Weekly (2008-07-01)

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