Monoclonal Antibodies

Research from Kinki University in the area of monoclonal antibodies published

Published in Cancer Weekly, July 1st, 2008

According to a study from Osaka, Japan, "We obtained unique cell-death-inducing monoclonal antibodies (mAbs) named D18 and D19 against chicken DT40 cells. D18 and D19 caused several signs of apoptosis, such as exposed phosphatidyl serine on the cell surface, a sub G(0)/G(1) peak, and DNA fragmentation, and inhibited the proliferation of DT40 cells."

"Flow cytometric and immunohistological analyses of various normal chicken tissues revealed the expression of the antigen recognized by these mAbs to be restricted to cells in lymphoid organs including bone marrow and bursa of fabricius, and to cells in some epithelial tissues. The cell death induced by the mAbs progressed...

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Source: Cancer Weekly (2008-07-01)

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