Neuroblastoma

New neuroblastoma research reported from M.H. Ni and co-authors

Published in Cancer Weekly, July 1st, 2008

According to recent research from Taiwan, "Collapsin response mediator protein-2 (CRMP-2), a phosphoprotein involved in axonal outgrowth and microtubule dynamics, is aberrantly phosphorylated in Alzheimer's disease (AD) brain. Alteration of glycogen synthase kinase-3 (GSK-3) activity is associated with the pathogenesis of AD."

"Here, we show that CRMP-2 is one of the major substrates for GSK-3 in pig brain extracts. Both GSK-3 alpha and 3 beta phosphorylate purified pig brain CRMP-2 and significantly alter its mobility in SDS-gels, resembling the CRMP-2 modification observed in AD brain. Interestingly, this modification can be detected in SK-N-SH neuroblastoma cells...

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Source: Cancer Weekly (2008-07-01)

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