Cancer Weekly
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Angiogenesis
Researchers from University of Oxford describe findings in angiogenesis
July 1st, 2008
According to recent research published in the journal Microvascular Research, "The Notch ligand, D114, is essential for angiogenesis during embryonic vascular development, and is involved in tumour angiogenesis. Several recent publications demonstrated that blockade of D114 signalling inhibits tumour growth, suggesting that it may constitute a good candidate for anti-cancer therapy." "In order to understand the role of D114 at the cellular level, we performed an analysis of D114-regulated genes in HUVECs. The genes identified included several angiogenic signalling pathways, such as VEGF, FGF and HGF. In particular we identified downregulation (VEGFR2, placenta...
Source: Cancer Weekly (2008-07-01)
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