Cancer Weekly
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Angiogenesis
Studies from University of Michigan in the area of angiogenesis described
July 1st, 2008
According to a study from the United States, "Connective tissue damage and angiogenesis are both important features of tumour growth and invasion. Here, we show that endothelial cells maintained on a three-dimensional lattice of intact polymerised collagen formed a monolayer of cells with a cobblestone morphology." "When the collagen was exposed to organ culture fluid from human basal cell tumours of the skin (containing a high level of active matrix metalloproteinase-1 (MMP-1)), degradation of the collagen matrix occurred. The major degradation products were the 3/4 and 1/4 sized fragments known to result from the action of MMP-1 on type 1 collagen. When endothelial...
Source: Cancer Weekly (2008-07-01)
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