Prostate Cancer

Data from University of Pittsburgh advance knowledge in prostate cancer

Published in Cancer Weekly, July 1st, 2008

"Protein kinase D (PKD) is a family of novel diacylglycerol/phorbol ester targets that regulate many important cellular functions including cell growth and survival. We now provide experimental evidence to indicate that PKD3 contributes to prostate cancer cell growth and survival," researchers in the United States report.

"Expression of PKD3 as well as PKD1 was significantly higher in human prostate tumors compared with normal tissues as revealed by immunohistochemistry. Moreover, PKD3 exhibited a marked increase in nuclear localization in tumor tissues, which correlated with tumor grade. Isoforms of PKD were differentially expressed and localized between normal and...

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Source: Cancer Weekly (2008-07-01)

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