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Apoptosis
Studies from L. Gan et al further understanding of apoptosis
July 1st, 2008
In this recent article published in the journal Acta Pharmacologica Sinica, scientists in Changsha, People's Republic of China conducted a study "To investigate the pro-apoptotic effects of alpha-1-adrenergic inhibitor doxazosin in HeLa cells and the potential involvement of transcription factor activator protein-2 alpha (AP-2 alpha) in doxazosin-induced apoptosis. The HeLa cells were exposed to various concentrations of doxazosin for 16 h. Apoptosis was detected using a DNA fragmentation assay, Hoechst 33258 staining, and flow cytometric analysis." "The expression of AP-2 alpha and caspase-3 was detected by relative quantitative RT-PCR and Western blot assays,...
Source: Cancer Weekly (2008-07-01)
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