Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy research has been reported by scientists at University of California
July 1st, 2008
According to recent research from the United States, "Effective treatment for recurrent, disseminated prostate cancer is notably limited. We have developed adenoviral vectors with a prostate-specific two-step transcriptional amplification (TSTA) system that would express therapeutic genes at a robust level to target metastatic disease." "The TSTA system employs the prostate-specific antigen (PSA) promoter/enhancer to drive a potent synthetic activator, which in turn activates the expression of the therapeutic gene. In this study, we explored different configurations of this bipartite system and discovered that physical separation of the two TSTA components into E1 and...
Source: Cancer Weekly (2008-07-01)
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