Brain Cancer

Investigators at University of California publish new data on brain cancer

Published in Cancer Weekly, July 1st, 2008

"Glioblastoma multiforme (GBM) is,the most common and lethal primary brain tumor in adults. We combined neuroimaging and DNA microarray analysis to create a multidimensional map of gene-expression patterns in GBM that provided clinically relevant insights into tumor biology," investigators in the United States report.

"Tumor contrast enhancement and mass effect predicted activation of specific hypoxia and proliferation gene-expression programs, respectively. Overexpression of EGFR, a receptor tyrosine kinase and potential therapeutic target, was also directly inferred by neuroimaging and was validated in an independent set of tumors by immunohistochemistry. Furthermore,...

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Source: Cancer Weekly (2008-07-01)

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