Myeloproliferative Disorders Genetics
INSERM details research in myeloproliferative disorders genetics
Published in Cancer Weekly, July 1st, 2008
Researchers detail in 'Common features of myeloproliferative disorders with t(8;9)(p12;q33) and CEP110-FGFR1 fusion: report of a new case and review of the literature,' new data in myeloproliferative disorders. "The 8p12 myeloproliferative syndrome is a rare, generally aggressive chronic myeloproliferative disorder (MPD). The hallmark of this MPD is the disruption of the FGFR1 gene, which encodes a tyrosine kinase receptor for members of the fibroblast growth factor family," scientists in Marseille, France report.
"In MPD cells FGFR1 is fused to several partners. The most frequent partner genes are BCR, CEP110, FOP, and ZNF198, localized on 22q11, 9q33, 6q27, and 13q12,...
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Source: Cancer Weekly (2008-07-01)
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