Cancer Weekly
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Gene Therapy
New gene therapy research from Tokyo University discussed
July 8th, 2008
"The suppression of gene expression of vascular endothelial growth factor (VEGF) which regulates tumor angiogenesis in vivo and is an important factor in tumor growth represents a novel approach to cancer treatment. Although small interfering RNA (siRNA) has rapidly become a major tool in gene therapy and is a key inhibitory factor of gene expression, its effect is temporary," scientists in Tokyo, Japan report. "The present study investigates the preparation of long-term sustained release poly (DL-lactic/glycolic acid) (PLGA) microspheres encapsulating anti-VEGF siRNA with a carrier (arginine or branched polyethylenimine) using the w/o/w in-water drying method and their...
Source: Cancer Weekly (2008-07-08)
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