Published in Cancer Weekly, July 8th, 2008
"Here, we report that compensating for the cancer-associated loss of a single glycosyltransferase, beta 1,4N-acetylgalactosaminyltransferese T2, dramatically decreased cell surface expression of both E-selectin ligands (sialyl Lewis(x) and sialyl Lewis(a)). This modification was associated with elevated expression of the Sd(a) carbohydrate determinant, which is expressed in normal gastrointestinal mucosa and is strikingly downregulated in cancer tissues," wrote...
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