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Cancer Gene Therapy
Researchers from Georgetown University describe findings in cancer gene therapy
July 8th, 2008
Fresh data on cancer gene therapy are presented in the report 'HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter function.' "The E6 and E7 proteins of high-risk HPVs are both required for the immortalization of primary human keratinocytes and the maintenance of the malignant phenotype of HPV-positive cancer cell lines. Our previous studies have shown that E6 protein binds Myc protein and that both E6 and Myc associate with and cooperatively activate the hTERT promoter, thereby increasing cellular telomerase activity," researchers in the United States report. "In this study, we evaluated the role of...
Source: Cancer Weekly (2008-07-08)
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