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Cancer Vaccines
Research on cancer vaccines detailed by scientists at University of Pennsylvania
July 8th, 2008
Data detailed in 'B-cell depletion using an anti-CD20 antibody augments antitumor immune responses and immunotherapy in nonhematopoetic murine tumor models' have been presented. "The role played by B cells in cancer biology is complex and somewhat controversial. Previous studies using genetically engineered mice suggest that B cells may be immunosuppressive and inhibit tumor rejection," scientists in the United States report. "However, the effects of B-cell depletion employing an antibody in mice bearing solid tumors has not been tested owing to difficulties in making an effective antimouse CD20 antibody (similar to rituximab). Injection of a newly developed antimouse...
Source: Cancer Weekly (2008-07-08)
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