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DNA Research
Scientists at Research Center discuss research in DNA research
July 8th, 2008
New investigation results, 'TLR9 as a key receptor for the recognition of DNA,' are detailed in a study published in Advanced Drug Delivery Reviews. According to a study from Suita, Japan, "Unmethylated DNA with CpG-motifs is recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Macrophages and conventional dendritic cells (cDCs) produce proinflammatory cytokines to B/K-type CpG-DNA, whereas plasmacytoid DCs induce type I interferons to A/D-type CpG-DNA and DNA viruses." "The TLR9 mediated signaling pathway is not only responsible for activation of innate immune cells, but also for mounting acquired responses. Thus, it has been...
Source: Cancer Weekly (2008-07-08)
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