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Adenomatous Polyposis Coli
Research on adenomatous polyposis coli described by P.R. Rao and colleagues
July 8th, 2008
According to recent research published in the journal Oncogene, "There have been conflicting reports on the requirement of GSK- 3 beta- mediated phosphorylation of the tumor suppressor adenomatous polyposis coli ( APC) vis-a-vis its ability to bind and degrade beta- catenin." "Using a unique combination of loss of function for Shaggy/ GSK- 3 beta and a gain of function for human APC in Drosophila, we show that misexpressed human APC ( hAPC) can still sequester Armadillo/beta- catenin. In addition, human APC could suppress gain of Wnt/ Wingless phenotypes associated with loss of Shaggy/ GSK- 3 beta activity, suggesting that sequestered Armadillo/beta- catenin is...
Source: Cancer Weekly (2008-07-08)
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