Cancer Weekly
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Adenovirus
New adenovirus study findings have been reported from Okayama University
July 8th, 2008
According to recent research published in the journal Oncogene, "Dendritic cells ( DCs) are the most potent antigen-presenting cells and acquire cellular antigens and danger signals from dying cells to initiate antitumor immune responses via direct cell- to- cell interaction and cytokine production. The optimal forms of tumor cell death for priming DCs for the release of danger signals are not fully understood." "OBP- 301 ( Telomelysin) is a telomerase-specific replication- competent adenovirus that induces selective E1 expression and exclusively kills human cancer cells. Here, we show that OBP- 301 replication produced the endogenous danger signaling molecule,...
Source: Cancer Weekly (2008-07-08)
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