Cancer Weekly
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Angiogenesis
New angiogenesis findings from M.T. Cibeira and co-authors described
July 8th, 2008
According to recent research from Barcelona, Spain, "An increased bone marrow (BM) angiogenesis is associated with poor outcome in multiple myeloma (MM). Angiogenesis study in MM treated with novel antimyeloma agents: thalidomide, lenalidomide, bortezomib, and with dexamethasone." "Forty-four patients with MM (14 newly diagnosed, 30 refractory/relapsed) were treated with novel agents at our institution. A BM biopsy was obtained before the initiation of therapy in 19. Angiogenesis was assessed by microvessel density (MVD) estimation in BM biopsies stained with the monoclonal anti-CD34 antibody, and by serum levels of angiogenic factors (VEGF, bFGF, and HGF) and cytokines...
Source: Cancer Weekly (2008-07-08)
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