Apoptosis

Reports outline apoptosis study results from Z.X. Du et al

Published in Cancer Weekly, July 8th, 2008

"Proteasome inhibitors are emerging as effective drugs for the treatment of relapsed/refractory multiple myeloma and possibly some solid tumors. Bcl-2-associated athanogene 3 (BAG3) is a survival protein that has been shown to be stimulated during cell response to stressful conditions, such as exposure to high temperature, heavy metals," researchers in Shenyang, People's Republic of China report.

"We have recently demonstrated that BAG3 is also induced by proteasome inhibitors at the transcriptional level and the induction of BAG3 by proteasome inhibition is antiapoptotic. Here, we demonstrated that although proteasome inhibitors triggered similar upregulation of BAG3...

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Source: Cancer Weekly (2008-07-08)

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