Colon Cancer Genetics
Data from Mie University, Institute of Life Science advance knowledge in colon cancer genetics
Published in Cancer Weekly, July 8th, 2008
Investigators publish new data in the report 'Mechanism of resistance to chemoradiation in p53 mutant human colon cancer.' "To understand one of the mechanisms of resistance to chemoradiation in colon cancer cells, we investigated whether 5-fluorouracil (5-FU) mediated the expression of epidermal growth factor receptor (EGFR) and modified repair of radiation-induced DNA damage, especially in a p53 independent pathway. Cytotoxicity was determined for 5-FU combined with radiation for three colon cancer cell lines that contain mutant p53 (SW480, HT29 and WiDr), using the WST-8 colorimetric assay," researchers in Tsu, Japan report.
"EGFR and the excision repair cross...
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Source: Cancer Weekly (2008-07-08)
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