Gene Therapy

Reports on gene therapy findings from Southern Illinois University, Medical Department provide new insights

Published in Cancer Weekly, July 15th, 2008

According to recent research from the United States, "MicroRNAs (miR-NAs) are a class of naturally occurring small non-coding RNAs that target protein-coding mRNAs at the post-transcriptional level. Our previous studies suggest that mir-21 functions as an oncogene and has a role in tumorigenesis, in part through regulation of the tumor suppressor gene tropomyosin 1 (TPM1)."

"Given that TPM1 has been implicated in cell migration, in this study we further investigated the role of mir-21 in cell invasion and tumor metastasis. We found that suppression of mir-21 in metastatic breast cancer MDA-MB-231 cells significantly reduced invasion and lung metastasis. Consistent with...

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Source: Cancer Weekly (2008-07-15)

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